狗心肌梗塞区心肌血管重建的实验研究:大网膜带蒂经皮下隧道移植

Reconstruction of Myocardial Blood Vessels in Cardiac Infarction in Dogs

本文用健康杂种狗13只(对照组3只,移植组10只),用30mg/kg硫喷妥钠静脉麻醉,气管内插管及开胸后分别结扎前降支的第2～4支和左旋支的钝缘支、侧支及一些细支,形成心肌梗塞区,然后剖腹将大网膜带血管蒂经皮下隧道移植于心肌梗塞区。4周后取出心脏,肉眼观察到大网膜与心肌之间有广泛性粘连,并可见粘连周围动脉吻合较明显;在镜下可见心外膜下心肌与大网膜移植部有明显的肉芽组织形成,心肌无明显坏死性变化,4周后的心电图上Q波基本消失,T波直立,心肌缺血基本恢复正常。

13 hybrid dogs were divided into 2 groups: 3 dogs in the control groups. and 10 in the transplant group. After the formation of cardiac infarction in transplant group by ligating 2-4 descending anterior and left marginal branches, the pedunculated greater omentum was transplanted to each cardiac infarction area of the transplant group through subcutaneous layer. There were not only extensive adhesions with formation of granulation tissue and arterial anastomosis between greater omentum and myocardium of subepicardial layer of cardiac infarction area, but also obvious hyperemia; no obvious myocardial necrosis happened at that area four weeks later.