四逆散对利多卡因毒性的影响

Effects of Sinisan on Lidocaine Toxicity

静脉注射四逆散2.5g/kg能救治利多卡因中毒,降低小鼠的死亡率,明显推迟其死亡发生的时间;腹腔注射四逆散5g/kg能显著预防利多卡因的毒性,并增加大鼠对利多卡因的耐受量。预防利多卡因毒性的半数有效量为6.1±0.69g/kg,随着四逆散的剂量增加其预防作用增强,呈显著的量效关系。

It was demonstrated that in mice Sinisan ( 2.5g/kg,i.v. ) could antagonige ahe lidocaine posining, decreaced its mortiity rate and prolonged survival time and ( 5g/kg,i.p. ) could prevent toxicosis, its ED50 is 6.1+.6g/kg, this effect is dependent on dose. In rats 5g/kg i.p. could significantly increased lidocaine ttolerance. These results suggest whether Sinisan may be considered lidocaine a toxieide.