心复康Ⅰ号的药效学研究(Ⅱ)——对冠脉流量、心肌缺血及心肌耗氧量的影响

The Pharmacodynamic -Study of Xin Fu Kang No. I(II) The effect on Blood flow of coronary artery, Ischemia and oxygen consumption of Heart muscle

实验表明:心复康Ⅰ号能显著增加离体豚鼠心脏冠脉流量,在1:4000浓度时不降低心肌收缩力及心率;对实验性大鼠心肌缺血有显著地对抗作用;还直接观察到心复康Ⅰ号对家兔实验性心肌梗塞后的心肌缺血有显著地保护作用,降低心肌耗氧量。

The effect of Xin Fu Kang No. I on the coronary blood flow of the isolated guinea-nig heart and the effect of myocardial ischemia of rats induced by the pituitary was studies. The results of the xperiments indiceted that when its oncentration was 1 : 4000 Xin Fa Kang No. I could markedly increase the coronary blood flow of the isolated guinea-pig heart without decreasing the force of myocardial contraction and the Heart rate. Xin Fu Kang No. I had marked the antagonistic effect on myocardal ischemia of the experimental rats. Protective effect of Xin Fu Kang No. I was directly observed in 27 rabbits with experimental myocardial infarction. Its characteristic was the decrease of the oxygen consumption in heart muscle .with significant difference between before and after the administration of the drug, and the test group and the control group.