冠心病患者发中十种微量元素及钙、镁的多元分析研究

A Multivariate Analysis of Ten Trace Elements and Ca,Mg in Hair from Men with Coranary Heart Disease

本文采用电感耦合等离子体-原子发射光谱法测定了50例冠心病患者和30名健康者发中十种微量元素及钙、镁含量,结果表明患者发中钼、锌、镁、钡、铬、钙含量降低。判别分析提示,发钙、铬、镁与冠心病关系较密切。对患者的与发病因素有关指标同其发中元素含量间相关关系进行多元分析的结果表明:血清总胆固醇、高密度脂蛋白-胆固醇、舒张期血压、体重水平、吸烟等指标分别与两种以上元素相关;收缩期血压、饮酒量分别与一种元素相关;血清甘油三酯水平与所测元素不相关。

The contents of ten trace elements(Mo, Fe, Zn, Mn, CU, Da, Sl, Co, Ni, Cr) and Ca, Mg in hair from fifty men suffered from coranary heart disease(CHD) and thirty control subjects were simultaneously deter-mined with inductively coupled plasma atomic emission spectrometer(ICP-AFS). The results show that the hair from CHD patients has decreased contents of Mo, Zn, Mg, Ba, Cr and Ca. Fisher′s discriminary analysis indicates that contents of Ca, Cr, Mg in more close relationship with CHD than others. In addition, the correlations among these elements were studied with stepwise regression analysis, some multiple regression equations have been set up. The correlations between some CHD risk indicators and contents of elements in hair from the patients were also studied. Our ruselts suggest that serum total cholesterol, HDL-cholesterol, diastolic blood pressure, level of weight, cigarette smoking has relations with two or more elements separately; systolic blood pressure, drinking only bear relationships wit ides has no raiation kith these elements.