砷和硒急性、蓄积性联合毒性的实验研究

Experimental Study of Acute and Accumulation Combined Toxicity of Arsenic and Selenium

用小鼠经口LD_(50)(半数致死量)为指标,研究三氧化二砷和亚硒酸钠的急性联合作用,其预期LD_(50)与实测LD_(50)的比值为0.52,根据Keplinger评价标准,二者具有拮抗作用。用固定剂量连续染毒法进行蓄积试验,砷、硒及其混合物的蓄积系数皆大于5,因此均为弱蓄积物质。

The acute combined action of As_2O_3 and Na_2SeO_3 was studied in mouse orally. The rate of predict LD_50 and determinal LD_50 was 0.52. According to the criterion of Keplinger, there was antagonistic action between them. The accumulative action experiment was done by exposuring to toxicant with fixed dose continually, and the accumulative coefficient of As_2O_3, Na_2SeO_3 and the mixture of them were all more than 5, so they were all weak accumulative substances.