三硝基甲苯(TNT)对人体外周血淋巴细胞微核率影响的研究

Study on Micronucleus Rate of Lymphocyte for Worker Exposure to Trinitrotoluene(TNT)

本文对54名TNT作业工人和20名病毒性肝炎患者及30名对照工人进行了外周血淋巴细胞微核率的观察。结果表明:TNT接触者微核率明显高于对照组;15年以上工龄组微核率明显高于1、4、8年工龄组;但TNT接触者与病毒性肝炎患者间无显著性差异。本文证实:TNT可以导致人体外周血淋巴细胞微核率的增高,引起染色体损害,长期接触其影响更大。

This article reports micronucleus rate of lymphocyte including 54 workers exposed to trinitrotoluene and 20 patients of viral hepatitis and 30 normal workers. The results showed micronucleus rate in workers exposed to TNT were significantly higher than control group; workers over 15 length of service group were significantly higher than 1, 4, 8 groups respectively. There were no significant difference between workers exposed to TNT and patients of viral hepatitis. Our study indicates that TNT induces to increase micronucleus rate of lymphocyte and to cause chromosome damage. The more length of service the more damage could be.