口服氨联吡啶酮治疗充血性心力衰竭的血液动力学效应

HEMODYNAMIC EFFECTS OF ORAL AMRINONE IN PATIENTS WITH CONGESTIVE HEART FAILURE

本文观察了14例充血性心力衰竭患者口服氨联吡啶酮的短期血液动力学效应,并与多巴酚丁胺的作用进行对比。结果显示,两种药均对多种原因的充血性心力衰竭有较好疗效,可增加心排血量、降低前后负荷,但氨联吡啶酮对心率、心肌耗氧量无明显影响,降低RA、SVR及增加SWI更为显著。

Amrinone, a synthetic hipyridine derivative, is a new nonlgycoside, noncatecholamine cardiotonic agent. It has been shown to have positive inotropic and vasodilating properties. This study was to evaluate the hemodynamic effects of oral amrinone in 14 patients of congestive heart failure(CHF)with dobutamine as control.After administration of amrinone, CI and SWI were significantly increased while PWP, SVR, PVR and RA decreased (P<0.05). The changes in SWI, SVR and RA by amrinone administration were more marked than those by dobutamine. However, there was no increase in myocardial oxygen consumption after amrinone administration. There was no untoward reaction during the entire course. It is concluded that amrinone is beneficial to the improvement of cardiac function in CHF as well as intractable heart failure.