测定肝炎患者血清尿酸含量的临床意义

CLINICAL SIGNIFICANCE OF SERUM URIC ACID LEVELS IN PATIENTS WITH HEPATITIS

测定了22例肝炎患者和12例正常人血清尿酸含量。结果表明各型肝炎患者血清尿酸含量均显著高于正常对照者;病死者的平均血清尿酸含量也高于患病存活者。其主要原因是肝细胞损伤,核苷酸降解增强和(或)ATP合成减少。血清尿酸是易测定的ATP降解标志物,可望作为评估肝炎患者功能障碍程度及其预后的一个参考指标。

The levels of serum uric acid in 22 patients with hepatitis and 12 normal controls were determined. The results revealed that the levels of serum uric acid in patients with all type hepatitis significantly are higher than normal controls and in mortal patients higher than survival patients. The causes of the levels increased of serum uric acid are chiefly due to hepatic cells being injured, the degradation increased of nucleotide and ATP synthesis decreased. Serum uric acid is a measurable marker of ATP degradation in body fluid. It is considered as a parameter to determine disorder of hepatic function, that can evaluate the prognosis of hepatitis patient.