贲门癌患者癌组织的多胺含量分析

DETERMINATION OF POLYAMINES IN THE TISSUE OF PATIENTS WITH CANCER OF THE GASTRIC CARDIA

本文报道了贲门癌患者癌组织的多胺含量变化,表明瘤组织的腐胺、精脒、精胺和总胺含量均高于近瘤组织和远瘤组织;而近癌组织又高于远癌组织,其升高幅度的顺序均表现为精胺>腐胺>精脒,增高出现率的顺序为腐胺>精脒>精胺。从而证明人体组织细胞癌变后,其多胺合成代谢增强,导致癌组织内的多胺含量增加。

This study deals with the variation in the amount of polyamines in the tissueof caneer of the gastric cardia. Results showed that putrescine, spermidine, sper-mine and total polyamine in the tissue of canceration (TOC) were all higherthan those found in the tissue near the canceration(TNC)and in that far from it(TFC). Irrespective of TOC or TNC, the rise pattern was invariably spermine>putrescine>spermidine. Therefore, it has been proved that after the tissue cellshave been cancerized, the senthetic metabolism of polyamines rises, leading to theelevation of the amount of polyamines in the cancerogenic tissue.