家兔出血性休克时眼球结膜、肠系膜和肾脏的微循环变化

A STUDY ON MICROCIRCULATIONS OF THE BULBAR CONJUNCTIVA,MESENTERY AND KIDNEY IN HEMORRHAGIC SHOCK RABBITS

观察和比较家兔出血性休克时眼球结膜、肠系膜和肾表面微循环,发现三者均发生微循环障碍,但表现并不完全一致。建立和应用荧光素肾血管造影法,表明休克时家兔肾内血液发生重分布。休克时血浆乳酸和血管紧张素Ⅱ、血清β-葡萄糖醛酸苷酶活力、血小板聚集功能和红细胞电泳时间发生变化,并参与微循环障碍的发生和发展。

Changes in microciroulations of the bulbar conjunctiva, mesentery and kidney; contents of plasma laotio acid, plasma angiotensin, serum β-glucuronidase; time for EBC electrophoresis and function of platelet aggregation were observed and measured before and during hemorrhagio shock in rabbits. Eenal blood flow distribution before and during hemorrhagio shook was determined by fluorescence angiography, a method estabolished in our laboratory. Eesults showed that microoirculatory disturbances in the three sites were obvious, but not quite similar in hemorrhagjo shook. The changes in conjunctival blood flow was noticed prior to constriction of conjunctival miorovessels; the changes in renal surface miorooiroulation occurred in reverse order as compared With those seen in conjunctiva; more obviously abnormal changes in the blood state than in the miorovessels were seen in the mesentery. During hemorrhagio shook, the greater part of blood was transferred from the cortex to juxtamedulla of the kidney, the contents of laotio acid, angiotensin and β-glucuronidase increased, the time for EBC eleotrophoresis was prolonged and the platelet aggregation rate decreased. It might be believed that increase in angiotensin is one of the cause of miorovasoular spasm and blood redistribution in kidney, that tho decrease in charge of EBC is related to the abnormal blood state, and that the increase in laotio acid and β-gluouronidase, the decrease in platelet aggregation rate are the results of the disturbances of miorooiroulation.