肝病患者血清尿激酶含量测定的临床意义

CLINICAL SIGNIFICANCE OF SERUM UROKINASE DETERMINATION IN PATIENTS WITH LIVER DISEASE

用放射免疫分析法测定90例肝病患者及74名正常人血清中尿激酶(UK)的含量。失代偿性肝硬化组(13例)的血清UK明显高于其他各组,达9.82±1.85ng/ml;其他组依次为:肝癌(16例)8.80±2.27ng/ml,慢性活动性肝炎(14例)8.33±1.69ng/ml;急性病毒性肝炎(15例)7.28±1.21ng/ml;其他疾病(32例)6.64±1.94ng/ml;正常对照组(74例)6.37±1.28ng/ml。大部分疾病组之间差别有显著性意义。肝病患者血清UK含量与血清白蛋白含量成负相关(p<0.05)。本实验提示,严重肝病时的出血倾向可能与肝脏对UK等纤溶激活物的灭活能力下降有密切关系。

Serum urokinase (UK) was determined in, 90 patients with various liver diseases and 74 healthy normal persons. Results showed that serum UK levels in the deoompensated liver cirrhosis group (n=13) was 9.82±1.85ng/ml, which was significantly higher than in any of the other groups. In the remaining groups, serum UK levels were follows: hepatooellular carcinoma (n= 16), 8.80±2.27ng/ml; chronic active hepatitis (n=14), 8,33±1.69ng/ml; acute viral hepatitis (n=15), 7.28±1.21ng/ml; other nonhepatic diseases. (n=32), 6,64±1.94ng/ml; andhealthy normal controls(n=74), 6.37±1.28ng/ml. Statistical significant differences existed between many of the diseased groups. A negative correlation existed between serum UK and serum albumin (p<0.05). It is suggested that a bleeding tendency in patients with severe hepatooellular damage might be closely related with decreased turnover of UK and other flbrinolytio factors in the diseased liver.