前列环素在流行性出血热休克中的作用

THE ROLE OF PROSTACYCLINE IN THE PATHOGENESIS OF SHOCK IN EPIDEMIC HEMORRHAGIC FEVER

1986～1988年开展了流行性出血热患者小静脉活检工作,获取发热期患者小静脉标本8份、休克期患者标本20份(其中14份重度休克)、对照组小静脉标本8份。测定了小静脉浸液对血小板聚集功能的抑制能力及其6-酮-前列腺索F_(1α)(6-k-PGF_(1α))含量。结果表明,重度休克患者小静脉浸液对血小板聚集功能无抑制作用,而其他各组小静脉浸液对血小板聚集功能均有抑制作用。同时测定各组浸液中6-k-PGF_(1α)含量,发现浸液对血小板功能的抑制能力与其6-k-PGF_(1α)量有密切关系。

Between 1986; 12 and 1988. 1, venular biopsy wag developed in epidemic hemorrhagio fever (EHF). These venular biopsy specimens were taken at different stages (8 patients in febrile stages, 20 patients in shook stage including 14 oases proved to be severe clinically), 8 specimens were taken, from non EHF persona serving as controls. The extracts from venules were incubated in Trig Buffer at 4℃, and the inhibitory potency on platelet aggregation and the quantity of 6-keto-prostaglandin F1α (6-k-PGF1α) were estimated. Experimental data suggested that in the stage of shock, especially in severe' shook; venular extracts did not prevent platelet aggregation and the 6-k-PGF1α content was low. There was interrelationship between 6-k-PGF1α content of tfte extract and the inhibition of platelet aggregation.