丹宁生物活化理论及其应用——Ⅰ.“丹宁生物活化假设”及其科学依据

THEORY OF TANNIN BIOACTIVATION AND ITS APPLICATION 1. Tannin Bioactivation Hypothesis and Its Scientific Basis

本文叙述了丹宁毒理机制研究中的主要争论。根据丹宁酸在试管内被稀酸水解为连苯三酚和没食子酸,栎叶丹宁在试管内经生物发酵产生多种低分子酚类化合物,提出“高分子水解丹宁经生物降解产生多种低分子酚类化合物引起中毒的假设”,并定义为“丹宁生物活化假设”,阐述了建立“假设”的科学依据。

This paper deals with main disputatin on the mechanism of Tannin Toxicosis.Based on Tannic acid and in vitro was hydrolized into gallic acid and pyrogallol by dilute acid;oak leaf Tannin in vitro produced many kinds of phenotic compounds with low molecular weights through biofermentation.The author proposes the hypothesis that Tannins can be hydrolized by high mo-leculars of oak leaves through biodegradation from which phenolic compounds with low moleculars cause toxicosis. Also, the author defines the hypothesis of bioactivation by Tannin,and deals with the scientific basis of forming the hypothesis.