心痛定与消心痛、心得安联合应用对缺血性心脏病患者疗效的比较

A Comparison of Therapeutic Effects of Nifedipine Combining with Isosorbide Dinitrate, Propranolol or Both in the Treatment of Ischemic Heart Disease

30名冠心病人随机分成三组,分别给予心痛定、消心痛、心得安的不同组合治疗。结果表明三药合用组在心绞痛发作次数、运动耐量、心电图及室壁运动等方面较二药合用组有更明显改善。说明经二种药物联合治疗仍未能满意控制的心绞痛患者,可加用另一种作用机理不同的药物以加强疗效。本实验尚应用超声心动图来观察室壁运动功能的改善,作为冠心病的疗效评价手段之一。

Thirty patients with ischemic heart disease (age 61.3112.08 years) were divided randomly into three administrations: Nifedipine plus isosorbide dinitrate (N +I, Nifedipine plus propranolol ( N + P ), Nifedipine plus isosorbide dinitrate and propanolol (N + I+ p). Each drug was given 30-70 mg Per day for an average duration of 3.2 monthes. The results show that the N + I + P treatment has been proved superior to N + I and N + p treatment in antiangina, exercise tolerate time, electricardiogram and ventricular wall motion. No significant changs are found in heart rate, mean blood pressure and left ventricular ejective fractinon. Our data prove that the addition of a different kind of antagonist is a worthwhile therapeutic in patients with double antagonists who have continuous anginal pectoris. Furthermore, we use two-dimensional echocardiography to observe wall motion improvement as an index for essesing the therapeutic effects in patients with ischemic heart disease.