淋巴细胞白血病免疫分型观察

The Study on Immunologic Classification with Lymphocytic Leukemias

免疫分型是淋巴细胞白血病的一种较为先进的分型法,能反映细胞来源与估计患者预后。本文应用抗人白细胞分化抗原的单克隆抗体,结合E_(?)-玫瑰花结试验及膜表面免疫球蛋白(Smlg)测定,将23例淋巴细胞白血病进行免疫分型,23例中普通型急淋19例,无标志型急淋2例,B细胞型急淋1例,B细胞型慢淋1例。发现普通型急淋的临床预后较其它类型急淋好。该分型法较传统的FAB分类法先进,

A immunologic classification of lymphocytic leukemias was carried out by using monoclonal antibodies against human leukocyte differentiation antigens. Besides, E-rosette formation test and direct immunofluorescent staining for Smlg were also included. With these monoclonal antibodies and immunological cell surface markers, 23 cases of lymphocytic leukemia were divided into C-ALL, Null-ALL, B-ALL and B-CLL. 19 cases of them were common type (C-ALL), 2 were Null-ALL,1i were B-ALL, and 1 were B-CLL.