幽门弯曲菌与十二指肠溃疡及慢性胃炎的关系

Relationship between Campylobacter Pyloridis and Duodenal Ulcer and Chronic Gastritis

100例十二指肠溃疡并慢性胃炎病人按完全随机方法分成两组,分别用雷尼替丁及三钾二橼络合铋治疗6周。结果为两组溃疡愈合率相似(P>0.05),但三钾二橼络铋治疗组幽门弯曲菌阴转率及慢性胃炎好转率高于雷尼替丁组(P<0.05),提示幽门弯曲菌与慢性胃炎有关,而与十二指肠溃疡关系不大。

One hundred patients with endoscopically diagnosed duodenal ulcers (DU) were randomised to receive either tripotassium dicitrato bismuthate(TDB) or ranitidine for 6 weeks. Antral biopsies were obtained at endoscopy before and after therapy to assess the changes of gastritis and the eradicating rates of campylobacter pyloridis (CP). The healing rates of DU were 76% for TDB and 60% for ranitidine (P>0.05)- CP were eradicated in 60% of patients receiving TDB, Comparing to 10.6% of those receiving ranitidine (P<0.05). Improvement of gastritis was more significant in patents treated with TDB than in those treated with ranitidine. We conclude: (1) The presence of CP do not affect the healihg of DU. (2) Eradication of CP is associated with a significant improvement of chronic gastritis. These findings strongly support the role of CP as a pathogen in causing gastritis but not contributing to DU.