乳腺癌凝集素受体的特异性及意义的探讨

The Specificity and Significance of Lectin Receptors in Breast Carcinoma

本文用8种凝集素对100例乳腺癌及56例非癌乳腺进行了亲合组化研究,发现Bandeiraea Simplifolia(BSL)、花生素(PNA)在乳腺癌阳性率高(75％、73.7％),主要为胞浆内定位;在正常乳腺和乳腺良性病变阳性率低,主要为乳腺小导管和腺泡的腔面定位(P<0.005)。作者认为花生素受体(PNA-R)在乳腺癌胞浆内的表达可能与肿瘤的免疫逃避有关。对正常乳腺的对比分析表明,PNA亲合组化对认识乳腺分化过程中糖基代谢的变化和乳腺癌的组织发生学有一定帮助。

Eight lectins were used to study 100 cases of breast carcinoma and 55 cases of non-carcinoma breast by lectin affinitive histochemical method. The result showed that Bandei-raea Simoplicifolia (BSL) and Peanut agglutinin (PNA) had higher Positive rates in breast carcinoma (respectively 75%, 73. 7%) than that in both normal breast and benign creast lesions (P<0.005), and the positive deposites in malignant lesions mainly located in cytoplasm while in non-malignant lesions they almost all lined along luminal cells(P <0.005)- The authors think that the expression of PNA-receptor in cytoplasm might be associated with the mechanism by which the tumour could flee man's immuno-system; the PNA affinitive histochemistry would be useful to undersand the metabolism of N-acetyl-D-galactosamino during the development of normal mammary and the histological origin of some breast carcinoma