摘要
棉酚可导致低血钾症已有实验证明.本文应用组织化学方法分析大鼠和豚鼠喂服棉酚及已知肾小管毒剂的庆大霉素(作为阳性对照)后肾的毒性损伤,着重研究在有关肾性失钾中,棉酚所起的作用。结果表明棉酚使肾小管膜酶暂时性减弱,影响重吸收功能.但和庆大霉素相比,棉酚不会引起肾小管细胞的结构损伤.
Gossypol has been shown to cause a side effect hypokalemia. This study was designed to evalulated the possible role of gossypol in relation to renal potassium loss by using histochemical method for comparative analysis of gossypol and gentamicin, a well known tubulo-toxic agent, as positive control with respect to nephrotoxic demage in rats and guinea pigs. The results indicated that gossypol had obvious effect on reabsorption function by inducing transitional decrease of membrane enzymes activities of renal tubular cells but had no effect as comparable with gentamicin to cause structureal damage of tubular cells.
出处
《解剖学报》
CAS
CSCD
北大核心
1989年第S1期33-36,110-111,共6页
Acta Anatomica Sinica
关键词
棉酚
低血钾
肾小管毒
gossypol
potassium loss
tubulo-toxic agent
