消炎痛抑制hCG诱发家兔排卵的研究Ⅰ

STUDY ON THE INHIBITION OF hCG INDUCED OULATION BY INDOMETHACIN IN RABBITS (Part 1)

消炎痛能有效地抑制CG诱发家兔排卵。采用放免分析动态测定循环血中的孕酮和睾酮,证实消炎痛虽然阻抑了排卵,但不影响甾体性激素的代谢。提示非甾体抗炎药可能是有开发价值的避孕药。

Rabbit ovulation induced by hCG was effectively blocked by indomethacin, an inhibitor of prestaglandin bicsynthesis. The levels of progesterone and testosterone in peripheral blood of rabbits were estimated by RIA at 5 min before and 45 min, 2, 3, 4, 8, 12 and 72 hours after hCG injection. No significant difference in the levels of the steroid hormones between indomethacin-treated group and control group were found. This suggests that indomethacin blocks ovulation of rabbits induced by hCG, but does not affect steroid hormone metabolism. It indicates non-sreroid anti-inflammatory drugs like indomethacin may become a hopeful anti-ovulatary drugs.