心房利钠因子和前激肽释放酶在原发性高血压发病中意义的探讨

A STUDY OF ATRIAL NATRIURETIC FACTOR IN PATHOGENIC MECHANISM OF ESSENTIAL HYPERTENSION

本文总结了心房利钠因子、前激肽释放酶在高血压病患者血浆中含量的改变。结果:①高血压病组血浆心房利钠因子含量明显高于对照组。②高血压病组血浆前激肽释放酶含量明显高于对照组。提示高血压病患者血浆的缓激肽含量可能减少。

The plasma levels of atrial natriuretic factor (ANF) and prekallikrein(PK) were measured in Fatients with essential hypertension and in health subjects as a control.The correlativity between the plasma level of ANF and that of PK was also analyzed. The plasma levels of ANF in hypertension group and in the control one were 175.95±109.53Pg/ml and 105.15±69.91Pg/ml (p<0.01) res(?)ectively. The plasma levels of PK in hypertension group and in control one were 83.05±33.50μm/ml/min and 50.88±4.14μm/ml/min (p<0.01) respectively. The cerrelative coefficient (r) between the plasma ANF and PK was 0.124 (P>0.05) in hypertension group.The increased Flasa level of ANF in essential hypertension might be the compensatcry reaction to high bleed pressure. The higher plasma level of PK showed that the decreased plasma level of bradykinin was probably one of the pathogenic factors in essential hyportension and it also suggested that the degradation and inactivation of ANF was decreased. There was no significant ccrrelation between the plasma ANF and PK in hypertension group.