成人急性白血病血浆纤维连接蛋白含量测定的意义

SIGNIFICANCE OF MEASUREMENT OF PLASMA FIBRONECTIN IN ACUTE LEUKEMIA

本文采用Beckman ICS行速率散射比浊法测定52例急性白血病患者和60例健康人血浆纤维连接蛋白(FN)含量,并对急性白血病未经化疗,化疗后未缓解,缓解及合并感染等情况进行分析。结果表明:未化疗组血浆FN在正常水平,化疗后未缓解组的血浆FN则显著低于正常对照组(P<0.001),化疗后缓解组的血浆FN趋于正常水平,化疗后合并感染组的血浆FN高于正常对照组但差异不显著(P>0.5)。提示血浆FN测定对于急性白血病的疗效观察和预后估计有参考意义。

Plasma fibronectin (P-FN) was measured by(?)a rate nephelometic method in two populations: healthy subjects (60 cases), patients (52 cases) with acute leukemia divided into four groups. Results showed that P-FN levels of the patients with acute leukemia prior to any chemotherapy were_lower than healthy subjects, but no significant difference between the two groups was found (P>0.2). The P-FN levels of the patients who did not obtain hematological remission were significantly lower than.that of the normal subjects (P<0.001) and that of the patients who obtained hematological remission (P<0.05).P-FN levels of the patients who obtained hematological, remission were within normal range. P-FN levels of the infected patients were higher than that of the noninfected patients, but without significant difference between the two groups(P>0.05) It is ccncluded that low P-FN is not directly related to tumor lcad or cpisodes of intercurrent infection, but correlated well with ehemotherapy. Measurement of P-FN appcared to be of some prognostic value in acute leukemia patients.