Ⅱ型糖尿病患者空腹血糖水平与口服葡萄糖—胰岛素分泌的关系

THE RELATIONSHIP BETWEEN FASTING BLOOD SUGARLEVEL AND ORAL GLUCOSE INSULINSECRETION IN NIDDM

本文对49名Ⅱ型糖尿病患者进行了口服葡萄糖—胰岛素释放试验,并按空腹血糖水平分组检测空腹血糖与胰岛素分泌之间的关系。结果表明,空腹时血糖与胰岛素水平无关,但是糖负荷后30、60、120和180min四个时相的胰岛素均值(sum form (IRI/4))明显低于正常对照组(P<0.001)。相比之下,糖负荷后总胰岛素释放指数(sum form (IRI)×100/(sum form (BS)))随着空腹血糖升高而逐渐下降。提示胰岛素周围利用减少是导致Ⅱ型糖尿病显著高血糖的主要原因。

The relationship between insulin secretion and fasting blood sugar level(FBS) was examined in 49 non-insulin-dependent diabetics (NIDDM) who were divided into 4 groups on the basis of FB S. Fasting and glucose-stimulated plasma immunoreactive insulin concentration (IRI) were not correlated with FBS in diabetics. But IRI after glucose-stimulation was significantly lower than that of normal subjects (P<0.001). In contrast, the total insulin secretion index ( ∑IRI × 100/ ∑BS) after glucose-stimulation decreased gradually with increasing of FBS in diabetics. Our results suggest that decrease of utilizing the peripheral insulin is the main reason to cause marked hyperglycemia in NIDDM.