松果体褪黑激素、神经肽及骨髓抑制因子在正常和肿瘤生长控制中的关系

LINKAE OF PINEAL MELATONIN,NEUROPEPTIDES AND BONE MARROW INHIBITORS FOR THE CONTROL OF NORMAL AND NEOPLASTIC GROWTH

作者证明小鼠褪黑激素是一种主要的免疫调节因子,按生理节奏注射褪黑激素能增强依赖抗原的 T 细胞免疫反应和拮抗因剧烈紧张引起的免疫抑制效应。作者认为骨髓微环境中含有抑制体内肿瘤生长的抑制物质。褪黑激素的抑制肿瘤作用与脑和淋巴细胞分泌的某些神经肽有相似之处,褪黑激素和某些神经肽对造血系统产生强烈的影响。作者推测褪黑激素的肿瘤抑制作用可能是通过鸦片样介导作用使骨髓产生抑制因子而发挥的。

The research demonstrated that melatonin is a main immunoregulatory agent and that its circadian administration enhances the immune response to T-cell dependent antigens and antagonizes the immuno- suppressive effects of acute stress in mice.It also showed that the bone marrow microenviroment contains potent tumor-suppressive subs- tances which inhibit tumor growth in vivo.Melatonin was found to possess oncostatic activty,similar to some neuropeptides secreted by the brain and by lymphocytes.Both melatonin and certain neu- ropeptides exert powerful effects on the hemopoietic system.It is proposed that the oncostatic effects of melatonin may be exerted via the opioids-mediated activity on production of bone marrow- derived inhibitors