摘要
本文探讨了体外培养小鼠肉瘤细胞经平阳霉素和钙阻断剂:VP和Tmb8;钙调素抑制剂:W13和TFP单独或同时处理后细胞增殖和存活率的变化,发现在IC10以内;VP和W13能够分别降低平阳霉素IC10值7、4倍和10倍;而Tmb8和TFP对平阳霉素IC10无显著影响;无毒剂量的VP和W13能显著增强平阳霉素的细胞毒性。
The proliferation and survival fraction of cultured mouse sarcoma cells treated with pingyangmycin (PYM) and calcium blockers: VP and Tmb8 cam inhibitors: wl3 and TFP alone or simultaneously were explored in this paper. It was shown that VP and wl3 within 1C10 decreased the IC50 for PYM by 7.4 and 10 folds respectively, but Tmb8 and TFP had very slight effects on the IC50 for PYM. Nontoxic—dose VP and wl3 enhanced the cytotoxicity of PYM apparently The results suggest that its hopeful to used VP and wl3 as antitumor enhancers of PYM in clinical.
出处
《川北医学院学报》
CAS
1989年第3期14-18,共5页
Journal of North Sichuan Medical College
关键词
钙阻断剂
钙调素抑制剂
平阳霉素
联合用药
Calcium blockers CaM inhibitors Pingyangmycin Combination of drngs