慢性肾功能衰竭与贫血关系的探讨

Relationship between Chronic Renal Failure and Anemia

本文分析了56例慢性肾小球肾炎所致慢性肾功能衰竭(GRF)患者的肾功能(血肌酐、血尿素氮)与贫血的关系。结果表明:血肌酐(Bcr)、血尿素氮(BUN)均与血红蛋白(Hb)值呈负相关,其中以 Bcr 与 Hb 负相关的相关系数较大;CRF 各期的 Hb 水平差异有显著性,在 CRF 代偿期,贫血患者占50%,氮质血症期73%贫血,尿毒症期100%贫血,且多为重度贫血。提示:肾功能越差,贫血越明显,以 Bcr 反映肾功能比 BUN 可靠;CRF 各期患者均可出现贫血,以尿毒症期最多,最严重;贫血程度在可逆性与不可逆性尿毒症的鉴别诊断中具有一定的实际应用价值。

The relationship between 56 patients'renal function and anemia, suffered from chronic renal failure(CRF)caused by chronic glomerulone- phritis was analysed.The result shows:1)The negative correlations between blood creatine(Bcr)and hemoglobin(Hb),and the blood urea nitrogen(BUN)and Hb are remarkable.2)Changing in Hb level among different stages of CRF is significant—the ratio of anemia is 50% in compensation stage of renal insufficiency,73% in nitremia stage and 100% in uremic stage.These suggest:1)The poorer renal function,the more serious anemia is.And it is more reliable to represent the renal function with Bcr instead of BUN.2)Anemia may appear in all of the patients with different CRF stages,but the most serious anemia appears in the uremia stage.3)The degree of anemia has its value in distinguishing reversible uremia from irreversible uremia.