摘要
At different,time after copper wire induced into the vitreous of the rabbits,malondialdehydes(MDA)in the retinas and trace element coppar in the aqueous humor and Pa-thology were observed.One day after the induction of copper,the level of MDA increasedabout three times in the retinas of experimental eyes as compared with the control eyes(p【0.01)and the amplitude of electroretinography(ERG)dropped rapidily following increase ofcopper ions in the vitreous.The tncrease of concentration of copper ions in the vitreous wasclosely correlated with that of MDA in the retinas (p【0.01).Early EM examination of ex-perimental eyes reveaisd damage of retinal membranous structure rich in oxygen andpolyunsaturated acid(PUFA),including the ovaer and inner segments of the photoreceptors.These results indicate thu copper-induced isptd peroxidation is an important cause of retinaldumage.
At different,time after copper wire induced into the vitreous of the rabbits, malondialdehydes(MDA)in the retinas and trace element coppar in the aqueous humor and Pa- thology were observed.One day after the induction of copper,the level of MDA increased about three times in the retinas of experimental eyes as compared with the control eyes (p<0.01)and the amplitude of electroretinography(ERG)dropped rapidily following increase of copper ions in the vitreous.The tncrease of concentration of copper ions in the vitreous was closely correlated with that of MDA in the retinas (p<0.01).Early EM examination of ex- perimental eyes reveaisd damage of retinal membranous structure rich in oxygen and polyunsaturated acid(PUFA),including the ovaer and inner segments of the photoreceptors. These results indicate thu copper-induced isptd peroxidation is an important cause of retinal dumage.
