摘要
A gross morphological classification of 66 small hepatocellular carcinomas (SHCC,≤3 cm in diameter)and a determination of the DNA-content in 20 SHCC and 26 LHCC(larger hepatocellular carcinoma,】3 cm in diameter)by image analysis technology were studiedin this paper.It was showed that SHCC could be divided into three types:Type I,non-capsule type (n=13,19.7％);type II,capsule type(n=47,71.2％) and Type III,infiltrative type (n=6,9.1％).The Type I and Type II SHCC mainly had diploid DNAstem line,while Type III SHCC mainly haa aneuploid DN A stem line.In patients with≤3cmSHCC,the postoperative 5-year survival rate was 75％,significantly higher than that of 42.3％in patients with】3 cm LHCC (P【0.05).There was no positive correlation between the tu-mor size and serum AFP level in this series.The results suggest that SHCC of≤3 cm in sizebasicaily reflects the relatively berugn btotogical characteristics of early hepatocellular carcinomaand is the best opportunity to acmeve the best curative results.But a small part of SHCC ex-presses markediy increased malignant biological behaviours due to the acceleration of stem lineselection.Up to now,as to the atscovery of the SHCC,the quantitative measurement of serumAFP level is still an effective and generally accepted method.
A gross morphological classification of 66 small hepatocellular carcinomas (SHCC, ≤3 cm in diameter)and a determination of the DNA-content in 20 SHCC and 26 LHCC (larger hepatocellular carcinoma,>3 cm in diameter)by image analysis technology were studied in this paper.It was showed that SHCC could be divided into three types:Type I, non-capsule type (n=13,19.7％);type II,capsule type(n=47,71.2％) and Type III, infiltrative type (n=6,9.1％).The Type I and Type II SHCC mainly had diploid DNA stem line,while Type III SHCC mainly haa aneuploid DN A stem line.In patients with≤3cm SHCC,the postoperative 5-year survival rate was 75％,significantly higher than that of 42.3％ in patients with>3 cm LHCC (P<0.05).There was no positive correlation between the tu- mor size and serum AFP level in this series.The results suggest that SHCC of≤3 cm in size basicaily reflects the relatively berugn btotogical characteristics of early hepatocellular carcinoma and is the best opportunity to acmeve the best curative results.But a small part of SHCC ex- presses markediy increased malignant biological behaviours due to the acceleration of stem line selection.Up to now,as to the atscovery of the SHCC,the quantitative measurement of serum AFP level is still an effective and generally accepted method.
