梗阻性黄疸血清锌、铜浓度改变研究

Serum Copper and Zinc Levels Study in Patients with Obstructive Jandice

微量元素锌、铜在体内参与许多物质代谢过程,具有重要的生理功能和营养作用。肝与锌、铜代谢关系密切,体内80%的铜经胆道排泄,胆汁排泄障碍时可引起血清铜的升高和铜/锌比值的改变。因此,我们对不同原因引起的阻塞性黄疸患者血清锌、铜浓度改变进行了初步研究,旨在探讨其变化规律和临床意义。

Serum copper and zinc levels were determined in 18 patients with obst- ructive jandice.Of these 18 patients,ten had cholelithiasis,eight had mal- ignant obstructive jandice.The serum copper levels Was significantly higher than that of the normal controls(P<0.01),especially,it was much higher in the patients with malignant obstructive jandice.But the serum zinc levels was lower in patients with obstructive jandice than that of the normal controls.