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Detrimental Effect of Free Radicals on Tissues in Rat with Burn Shock

Detrimental Effect of Free Radicals on Tissues in Rat with Burn Shock
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摘要 A model of burn shock was reproduced in rats and the changes of water content andmalondialdehyde(MDA)concentration in tissues were measured.The results showed that there wasa significant increase of MDA concentration and water content in lung and bumed skin post burnand a positive correlation was found between MDA level and water content.Pretreatment withsuperoxide dismutase(SOD)prevented effectively lung and skin from edema.The role of oxygen freeradicals in vascular permeability disturbance and development of edema in burns was discussed. A model of burn shock was reproduced in rats and the changes of water content and malondialdehyde(MDA)concentration in tissues were measured.The results showed that there was a significant increase of MDA concentration and water content in lung and bumed skin post burn and a positive correlation was found between MDA level and water content.Pretreatment with superoxide dismutase(SOD)prevented effectively lung and skin from edema.The role of oxygen free radicals in vascular permeability disturbance and development of edema in burns was discussed.
出处 《Journal of Medical Colleges of PLA(China)》 CAS 1989年第2期108-110,共3页 中国人民解放军军医大学学报(英文版)
关键词 shock BURNS free RADICAL lipdperoxidation malondialdehyde(MDA) shock burns free radical lipdperoxidation malondialdehyde(MDA)
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