摘要
The changes of sclenium metabolism, glutathione peroxidase activity and lipid peroxidescontent in the tissues of rats suffering from 30% TBSA full thickness scalding were observed in thefirst 7 days after injury. It was found that selenium content in the rat tissues decreased remarkably af-ter injury, which in turn resulted in serious reduction of glutathione peroxidasc activity and significantincrease of lipid peroxides in the scrum, crythrocytcs and liver. However the muscular tissue showedno significant changes. These facts imply that after burn injury, the body is in a state of selenium deficiency, the lossof selenium might be responsible for the reduction of anti - peroxidation ability of glutathioneperoxidase, and conscqucntly there is an increase of lipid peroxides in the tissues. Only the musculartissue is insensitive to lipid peroxidation. It is believed that the reduction of anti-peroxidation abilityof glutathione peroxidasc after bum injury might be one of the main causes to intensify, the injury re-suiting from free radicals.
The changes of sclenium metabolism, glutathione peroxidase activity and lipid peroxides content in the tissues of rats suffering from 30% TBSA full thickness scalding were observed in the first 7 days after injury. It was found that selenium content in the rat tissues decreased remarkably af- ter injury, which in turn resulted in serious reduction of glutathione peroxidasc activity and significant increase of lipid peroxides in the scrum, crythrocytcs and liver. However the muscular tissue showed no significant changes. These facts imply that after burn injury, the body is in a state of selenium deficiency, the loss of selenium might be responsible for the reduction of anti - peroxidation ability of glutathione peroxidase, and conscqucntly there is an increase of lipid peroxides in the tissues. Only the muscular tissue is insensitive to lipid peroxidation. It is believed that the reduction of anti-peroxidation ability of glutathione peroxidasc after bum injury might be one of the main causes to intensify, the injury re- suiting from free radicals.
