乙型肝炎补体Cl激活的研究

Complement Cl action in viral hepatitis B

作者测定88例 HBV 感染的急肝、慢肝、重型肝炎和肝炎肝硬化患者的 Clg、Clr、Cls 和 CiINH,并探讨其变化之意义。发现患者 Cl 明显激活,血清 Cls 减少与病情轻重有关,Cls 水平随肝脏损伤加剧而下降。CiINH 消耗增多、合成减少,不能有效地调控Cl 活化。认为测定血清 Cls 对研究补体经典途径活化、探讨乙肝发病机理、判断患者肝脏损害程度及估计预后都有一定的意义。

This paper reported the results of detecting serum Clq,Clr,Cls and C(?)INH in 88 patients with various types of viral hepatitis B and discussed the clinical significance of their changes.Thedata confirmed that Cl was apparently activated in these patients, and serum Cls reduced,which related well with the extent of hepatic damage.ClINH consumption incresed and its synthesis decreased.Thus it couldn't effectively regulate Cl acttivation.The determination of serum Cls levels may be of value for study on complement classical pathway activation and the pathogenesis of hepatitis B,estimation of the extent of hepatic damage in the patients and evaluation on prognosis.