手术与放射治疗视网膜母细胞瘤

COMBINED SURGERY AND RADIOTHERAPY IN THE TREATMENT OF RETINOBLASTOMA

视网膜母细胞瘤是危及婴幼儿生命较严重的眼病,且为多中心起源,预后常不良。本文对我院1958～1983年间,经手术与放射治疗的视网膜母细胞瘤,观察满五年以上的161例其中存活五年以上82例进行临床分析,并讨论其影响预后的因素。

161 patients with retinoblastoma treated by combined surgery and radiotherapy from 1958 to 1933 are presented. Eighty-two patients who have survived for more than 5 years were analysed. The prognostic factor study showed that those with courses under6 months, eary lesion (stage Ⅰ) , no tumor invasion in the optic nerve and postoperative radiation dose of 30 Gy had favorable outcome. In the whole group, the 5, 10, 15 and 20 year survival rates were50.9% (82/161) , 47.5% (58/122) , 38.1% (32/84) and 20.0% (9/45) , respectively.The. authors suggest that the. early lesions be treated by operation. Those with possible residual lesions should be supplemented with radiation treatment. For the other stage lesions, postoperative radiation should be used to deliver 30-40 Gy by linear acce lerator, high energy electron beam or deep X-rays.