腔内微波加热并用放射治疗对非手术直肠癌患者的随诊观察

INTRACAVITARY MICROWAVE HYPERTHERMIA COMBINED WITH RADIOTHERAPY FOR INOPERABLE RECTAL CANCER

为了提高直肠癌根治术后的5年生存率,我院于1984年开展了直肠癌术前放疗并用腔内微波加热治疗。两者并用临床症状改善明显,病理学证实癌细胞退变显著,20％病例的癌细胞完全消失。

Fifteen patients with inoperable advanced rectal cancer were treated by radiation combined with hyperthermia. Eleven patients refused surgery, 2 could not tolerate anesthesia and 2 had lesions - considered unresectable. Radiation doses ranged from 30-40 Gy/4 wk. Hyperthermia was given by a 915 MHz microwave intracaviary applicator. The. temperature at the center of cancer surface was 45-50℃. Heating was given 30 minutes after radiation, for 45 minutes twice a week.After 25-43 months follow-up, the 2 and 3. year survival rates were 11/13 (85%) and 8/10 (80%) respectively. Three patients died of local recurrence and 1 of liver metastasis. However, all 5 patients who received radiation of 68-70 Gy are alive.Of the 11 surviving patients, 5 showed complete response (CR) , 5 showed partial response (PR) and 1 had recurrence. It is suggested that combination of radical radiation with hyperthermia may be usefull for patients who had early lesion but could not tolerate surgery or refuse operation.