小剂量青霉胺治疗类风湿性关节炎的观察

Use of smaller noses of D-penicillamine in rheumatoid arthritis

类风湿关节炎(RA)的治疗是个棘手的问题,非甾体抗炎药虽能缓解关节炎症,但不能阻止疾病的进展。近年来,我国已开始采用慢作用制剂,如青霉胺等治疗RA,但由于使用剂量大,副作用多,患者难以坚持长期治疗。本文总结使用小剂量青霉胺治疗RA15例的观察结果。

Fifteen patients with rheumatoid arthritis were treated with smaller doses of D-penillamine (250mg/day) and were followed up for 23 months. Eighty-six percent of patients whose disease was in active phase got complete remission after the treatment. Meanwhile, the serological and immunologioal abnormalities, such as ESR, CRP, IC, r-globulin and immunoglobulins, returned to normal. The RF in one third of the patients became negative, and its titer in the remaining 8 seropositive RA decreased remarkably. In comparison with the regimen of large dose of penicillamine, this group show much milder side effect.