周围神经再生时远端对近端趋化作用的实验研究

Neurotropic effects of distal stumps on proximal stumps in rat sciatic nerve regeneration:Tissues specificity

周围神经损伤修复以后,神经功能的恢复常不理想,原因之一就是在神经修复术中不能将每根神经纤维的近端与其相应的远端准确无误地接起来,造成再生神经纤维的错向生长。长期以来,控制再生神经的生长方向、解决错向生长的问题一直是摆在科学家面前的一个难题。Ramon y

In this experiment, 44 rats were studied. The left sciatic nerve was transected. The proximal and distal stumps, tendon as well as vacancy were orderly introduced into the inlet and outlets of silastic Y-chamber or cross-chamber. 4 weeks later, the direction of nerve growth was observed. It was showed that proximal stump grew towards the distal stump rather than to the tendon and vacancy outlets. This indicats that there is of neurotropism or chemotaxis during rat peripheral nerve regeneration, which may be called tissue specificity. The chemotactic mechanisms, the distance between proximal and distal stumps and selective utilization of silastic material are discussed.