马氏蝎毒抗惊厥作用的初步研究

Effect of the scorpion venom of buthus martemsii karsch against convulsion

近年来国内外对蝎毒的研究工作已开展了不少,我国蝎毒的资源比较丰富,马氏蝎作为名贵中药应用于临床,自宋朝以来就有记载,本草纲目记载:“蝎主治手抽掣,小儿惊痫风搐”历来中医均认为蝎尾的疗效要高于全蝎,显然其作用主要为蝎毒。彦行伍等证明全蝎干粉对戊四氮、士的宁、烟碱有抗惊厥作用。于佩玉等证明蝎毒静脉或脑室注射均使ECOG波幅减小。本文对马氏蝎毒的抗惊厥作用进行了初步研究。

In this paper, the anticonvulsive effect of the crude scorpion venom of Buthus artensii Karsch (BMKV)were reported. Pentylenetrazle (PTZ), strychnide, picrotoxin, emicarbazide, and maximal electroshock induced seizures were investigated in mice. The mice eceived normal saline served as controls. We found that BMKV had the protective effect against onvulsion induced by PTZ and strychnine. At the same time, we also revealed that the BMKV had edative effect on mice spontaneous movement. Therefore, as shown in our experiments, the nticonvulsant action of the whole scorpion as documented in traditional chinese medicine, may ave a combined action of anticonvulsive and sedative effects.