老年人PFK抑制试验正常值和老年人癌的早期诊断

Normal value of PFK-jnhjbition test in the aged and its use for early diagnosis of cancer

中老年癌发生率较高,如何提高疗效,关键是早期诊断,以便在癌发生转移前实行有效的疗法。中村氏提出PFK(磷酸果糖激酶)抑制试验能发现人体内极小的癌肿,可作为癌早期诊断的过筛方法。我们对该法进行了改进,测定了73例健康老年前期和老年人血清PFK抑制率,并对52例确诊癌瘤老年前期和老年患者的血清作了相同的测定,以评价该法应用的前景。

Early detection is essential in the management of patients with cancer. PFK-nhibition test is a new method for detecting cancer in its early stage, and has been proved to e more sensitive than the prevailing screening test such as AFP or CEA. Sera from cancer atients specifically suppressed PFK. The PFK-inhibition rate(％) of 73 normal sera from ealthy ged (54-57 years old) with an average of 61.8 is 10.0±0.340 (?)±SEM); of 31 sera from benign iseases 54.2 years old in average is 26.6±0.598 ((?)±SEM); of 52 sera from cancer patients averagely 62.0 years old) is 43.7±0.476 ((?)±SEM). It is evident that the Value of serum rom ancer patient is significantly different from that in healthy subject or patient with benign iseases (P<0.01), These results suggest that PFK-inhibition test may serve as an useful arameter in the monitoring and early detection of cancer.