摘要
目的通过比较分析^131I对青少年和中老年甲状腺功能亢进(甲亢)的临床疗效,探讨^131I治疗青少年甲亢的可行性。方法940例在山东大学齐鲁医院及山东省立医院进行^131I治疗的甲亢患者入选,按年龄分为3组,青少年组(〈25岁):106例患者,中年组(25-60岁):768例,老年组(〉60岁):66例。随访2年,分析3组的疗效差异。结果青少年组痊愈46例(43.4%),好转34例(32.1%),甲减24例(22.6%),无效2例(1.9%),有效率为98.1%;中年组痊愈346例(45。1%),好转260例(33.9%),甲减140例(18.2%),无效22例(2.9%),有效率为97.1%;老年组痊愈28例(42.4%),好转24例(36.4%),甲减10例(15.2%),无效4例(6.1%),有效率为93.9%。X^2检验显示各年龄组间痊愈率、好转率、甲减率、无效率之间差异均无统计学意义(均P〉0.05)。结论青少年甲亢患者接受^131I治疗效果与中老年患者无差异,^131I治疗青少年甲亢是有效、可行的。
Objective To investigate the efficacy and safety of ^131I therapy on hyperthyroidism in adolescents, middle-aged people, and the elderly. Methods 940 patients with hyperthyroidism, 106 aged 〈 25 (Group A, group of young people), 768 aged 25 - 60 ( Group B, middle-aged group), and 66 aged 〉60 (Group C, group of the elderly) , underwent ^131I therapy and were followed up for 2 years to evaluate the efficacy and safety. Results Forty-six patients in group A (43.4%) became euthyroid, 34 ( 32.1% ) turned better, 24 (22.6%) suffered from hypothyroidism, and 2 (1.9%) remained un-changed, with a general effective rate of 98.11% (104/106). 346 patients (45. 1% )in Group B became euthyroid, 260 (33.9%) tumed better, 140 (18.2%)suffered from hypothyroidism, and 22 (2.9%) remained un- changed, with a general effective rate of 97.14% (746/768). And 28 patients(42.4% )in Group C became euthyroid, 24 ( 36.4 % ) turned better, 10 ( 15.15 % ) suffered from hypothyroidism, and 4 ( 6.1% ) remained unchanged, with a general effective rate of 93.93% (62/66). There were not significant differences in the recovery rate, improvement rate, hypothyroidism rat, and ineffective rate among the 3 groups (all P 〉 0.05). Conclusion There are no significant differences in the efficacy and safety of ^131I therapy in hyperthyroidism on the patients of different ages, including adolescent, adult and elder persons. ^131I therapy is safe and effective for adolescents.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第14期973-976,共4页
National Medical Journal of China