857例清开灵注射液不良反应报告分析

Analysis Report on 857 cases of Qingkailin Injection Adverse Drug Reactions

目的探讨清开灵注射液不良反应发生原因,为临床合理用药提供参考。方法采用描述性分析的方法对贵州省不良反应监测中心数据库中2003～2008年清开灵注射液不良反应病例报告进行统计分析。结果清开灵注射液不良反应的发生与性别无关,临床表现主要为过敏反应(305例,占35.59%)和全身性损害(417例,占48.66%),不良反应在30min内发生者有652例,占76.08%。结论临床医师、药师应重视清开灵注射液的不良反应,坚持合理用药,并在用药过程及用药后加强观察。

Objective To investigate drug adverse reactions caused by Qingkailing injection, in order to provide a reference for clinical drug rational use. Method 2003 - 2008 Qingkailing Injection Case reports of adverse reactions collected from the Guizhou Province Monitoring Center Database was analysed descriptively. Result The occurrence of Qingkailing injection adverse reactions was not correlated to gender. The clinical manifestation was mainly for allergic reactions （305 cases, accounting for 35.59% ） and systemic damage （417 cases, accounting for 48.66% ）. There were 652 cases adverse reactions occurred in 30min accounting for 76.08%. Conclusion Clini- cal physicians, pharmacists should attach importance to Qingkailing injection adverse reactions, persist in rational drug use and focus on the observation,after druguse.