中医肾生髓理论在抗衰老与临床实践中的应用

The Applications of Traditional Chinese Medicine Theory "Kidney Produce Marrow" in Aging Delay and Clinical Practice

目的探讨肾藏精生髓理论在中医延缓衰老研究终的应用。方法采用多种动物模型[辐射损伤模型、溶血性血虚模型、马利兰诱发骨髓造血障碍模型、阉割公鸡模型、去势大鼠、老龄大鼠、半乳糖致衰老大(小)鼠、O3促老化小鼠、老龄金黄地鼠、老龄鹌鹑、五龄家蚕等],探讨补肾生血药延缓衰老机制,并运用补肾生血药治疗β-地中海贫血。结果运用中医肾藏精、生髓、髓生血理论在延缓衰老研究及中药治疗β-地中海贫血研究中均获得明显效果。研究揭示了中医肾藏精生髓理论的科学内涵。结论中医肾藏精生髓理论是延缓衰老研究和中药治疗单基因遗传病(β-地中海贫血)的重要理论基础之一。

Objective To investigate the clinical usage of Traditional Chinese Medicine Theory ＂kidney produce marrow, marrow produce blood, marrow and blood originate from kidney＂ in aging delay. Methods Several animal models （including radiation damaged, hemolytic anemia, Myrelan induced haematopoietic impedient anemia, emasculated rooster, emasculated rat, aged rat, glucose induced senescence rat/mouse, ozone induced aged mouse, aged Golden hamster, aged partridge and the fifth instar larva of silkworm etc） were applied to study the mechanism of the aging delay, and ＂ Bushenshengxue＂ medicine were also used in treating β-thalassemia patients. Results Significantly results were observed both in aging delay study guided by Traditional Chinese Medicine Theory ＂kidney produce marrow, marrow produce blood, marrow and blood originate from kidney＂ and in β- thalassemia clinical study. The results indicated the science connotation of this theory. Conclusion The Traditional Chinese Medicine Theory ＂kidney produce marrow, marrow produce blood, marrow and blood originate from kidney＂ is the main basic mechanism of aging delay and single gene heredity disease treating with TCM.