脑胶质瘤危险因素的病例对照研究

Casecontrol Study on Risk Factors of Glioma

采用１∶２配比的病例对照研究方法及Ｌｏｇｉｓｔｉｃ模型分析。单因素分析提示吸烟年限超过３０年、饮白酒年限超过３０年、头部外伤、暴露铅、放射线、汽油柴油、农药及家庭一级亲属癌症史与脑胶质瘤的发生有联系。多因素分析发现家族一级亲属癌症史、放射线与脑胶质瘤有关联。

A hospital based 1∶2 casecontrol study was performed.The risk factors of glioma were analyzed by conditional logistic regression. The results of unvariable analysis showed that there was significant association between glioma and drinking alcohol period over 30 years, smoking period over 30 years, exposing head trauma, lead, radioactivity,diesel oil, gasoling, pesticide and the familial history of cancer in the first degree relatives. We found that the familial history of cancers in the first degree relatives and radioactivity expose were associated with glioma by the multivariable analysis. 