正骨通痹丸对糖皮质激素致骨质疏松大鼠骨代谢障碍的改善作用

Effect of Zhenggu Tongbi Pill on Bone Metabolic Disorders in Glucocorticoid Induced Osteoporosis Rats

目的::观察正骨通痹丸对地塞米松所致骨质疏松大鼠的骨代谢的影响。方法:采用8周龄Wistar大鼠地塞米松肌注8周建立糖皮质激素性骨质疏松动物模型。模型成立后,模型组灌胃每天给予蒸馏水10ml/kg,正骨通痹丸各剂量组每天分别给予正骨通痹丸1.35、2.7、5.4 g/kg。给药12周后,测血清ALP、血清StrACP及尿HOP的含量等。结果:模型组大鼠尿HOP含量显著升高,正骨通痹丸5.4g/kg剂量组及仙灵骨葆组与模型组相比,尿HOP含量显著降低。与正常对照组相比,模型组大鼠血清StrACP活性显著增加,同时血清ALP活性显著下降,正骨通痹丸剂量依赖性的对抗地塞米松所致的血清StrACP活性的增加及血清ALP活性的降低。结论:正骨通痹丸可对抗地塞米松所致骨质疏松大鼠骨代谢紊乱。

Objective：To investigate the effect of Zhenggu Tongbi Pill（ZTP） on bone metabolism in dexamethsone induced osteoporosis rats.Methods：Wistar rats（8 weeks old） received intramuscular injection of dexamethasone（2.5 mg/Kg,twice a week） for 8 weeks to establish osteoporosis model.Model group were treated with intragastric administration of distilled water at the dosage of 10ml/Kg while treatment group received ZTP at the dosage of 1.35,2.7 and 5.4 g/Kg respectively for 12 weeks.Serum ALP,serum StrACP and urine HOP were detected.Results：Compared with model group,urine HOP was significantly decreased after treated with ZTP of 5.4g/kg and Xianling Gubao.Compared with the control group,serum StrACP was significantly increased and ALP significantly decreased in the model group.Serum StrACP was decreased and ALP increased after ZTP treatment with dose dependent style.Conclusion：ZTP an effectively prevent bone metabolism disorder caused by dexamethsone.