辛伐他汀对不稳定型心绞痛患者血脂和炎症指标的影响

Effect of Simvastatin on Blood Lipid and Inflammation Target in Patients with Unstable Angina Pectoris

目的观察辛伐他汀治疗不稳定型心绞痛患者15天后血脂、高敏C反应蛋白、一氧化氮、丙氨酸氨基转移酶和肌酸激酶的变化。方法将98例不稳定型心绞痛患者随机分为20mg/d辛伐他汀组(34例)、40mg/d辛伐他汀组(32例)和对照组(32例);所有病例均测定治疗前及治疗15天后血脂、高敏C反应蛋白、一氧化氮、丙氨酸氨基转移酶和肌酸激酶的变化。结果辛伐他汀治疗组治疗前后比较以及与对照组比较,血脂、高敏C反应蛋白明显下降(P<0.05),且40mg/d组下降更明显;辛伐他汀治疗后两组丙氨酸氨基转移酶水平升高,但均未超出正常值3倍;一氧化氮和肌酸激酶治疗前后差异无显著性。结论在不稳定型心绞痛早期使用较大剂量辛伐他汀治疗15天,可明显且安全地减轻炎症,降低血脂。

Aim To observe effect of simvastatin on blood lipid and inflammation target in patients with unstable angina pectoris （UAP）. Method Ninety-eight patients with UAP were randomly assigned into control group （ n = 32 ） treated without lipid-lowering drugs, 20 mg [ n = 34 ） and 40 mg （ n = 32） simvastatin groups administrated simvastatin 20 mg/d and 40 mg/d respectively for 15 days. Blood levels of high sensitive C reactive protein （ hs-CRP）, nitric oxide （ NO）, alanine aminotransferase （ ALT）, creatine kinase （ CK） and lipid were all detected before and after the treatment. Results On the 15th day of the trentment, the levels of hs-CRP and lipid were all reduced, especially in 40 mg/d simvastatin group. While the levels of ALT were elevated markedly in 20 mg/d and 40 mg/d simvastatin groups, but the levels of ALT did not exceed the three times of the normal levels, the levels of NO and CK were not changed. Conclusion Treatment with high dose of simvastatin for 15 days in patients with UAP could reduce inflammation and lower blood lipid safely.