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脂蛋白在动脉粥样硬化发病中的分子机制及其干预 被引量：1

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摘要 "滞留-应答"学说提出动脉粥样硬化的起始步骤是含载脂蛋白B的脂蛋白与内皮下基质相互作用导致脂蛋白在内膜下滞留。鉴于动脉粥样硬化发病的分子机制,直接干预血浆脂蛋白已取得显著的临床效益。阻止含载脂蛋白B的脂蛋白与特异性内皮下基质分子的相互作用及阻断辅助分子,如脂蛋白脂酶、分泌性鞘磷脂酶,为治疗动脉粥样硬化性疾病提供新的干预靶点。
作者 陈雅琴 赵水平
机构地区 中南大学湘雅二医院心内科
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2009年第2期166-168,共3页 Chinese Journal of Arteriosclerosis
关键词 脂蛋白 基质分子 脂蛋白脂酶 分泌性鞘磷脂酶 蛋白多糖
分类号 R543.5 [医药卫生—心血管疾病] R541.4 [医药卫生—心血管疾病]
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参考文献24

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二级参考文献47

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中国动脉硬化杂志
2009年 第2期

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