替米沙坦与吲哒帕胺联合治疗高血压的临床疗效

The clinical effect of telmisartan combined with indapamide in treatment to hypertension

目的评价替米沙坦与吲哒帕胺联用治疗轻、中度高血压的临床疗效与安全性。方法采用随机平行对照方法，将原发性轻、中度高血压患者74例分成3组。对照组（n=24）予以替米沙坦（40mg／d，每日1次）；治疗组Ⅰ（n=25）在服用替米沙坦（20mg／d）基础上，加服吲哒帕胺（1．25nag，每日1次）；治疗组Ⅱ（n=25）在服用替米沙坦（20mg／d）基础上，加服酒石酸美托洛尔（25mg，每日2次）。疗程均为8周。结果治疗8周后，治疗组Ⅰ和治疗组Ⅱ，总有效率分别为92．0％和83．3％，前者与对照组总有效率62．5％比较，P〈0．05；后者与对照组比较，P〉0．05。对照组、治疗组Ⅰ和治疗组Ⅱ不良反应发生例数分别为4、3、1例。结论低剂量替米沙坦与吲哒帕胺联用治疗轻、中度高血压较单用替米沙坦降压效果好。

Object To evaluate the antihypertensive efficacy and safety of telmisartan. Methods Seventy -four patients with mild to moderate essential hypertension were randomly divided into 3 groups ： the test groupⅠ （ n = 25 ） to receive telmisartan 20 mg and indapamide 1.25 mg, the test group Ⅱ （ n = 25 ） to receive telmlsartan 20 mg and metoprolol tartrate 25 mg,bis in die;the controlled greup（n =24）to receive telmisartan 40 mg,once -daily. Results After 8 week of therapy,the total efficiency of the test group J, the test group D and the controlled group were 92. 0%, 83. 3 %, 62. 5 %, respeetively. Ⅰ and treatment set Ⅱ of the matched control, treatment set responds the occurrence number to distinguish to 4, 3 and 1 badly. The results showed that there were significant differences in the efficiency between the test group Ⅰ and the controlled group. Conclusion The results suggest that antihypertensive effects of the test group is more safe and better in treatment of hypertension.