中药胃动方联合铝碳酸镁治疗胆汁反流性胃炎的临床研究

Effect of Weidongfang and hydrotalcite on bile reflux gastritis

目的观察胃动方联合铝碳酸镁治疗胆汁反流性胃炎的效果。方法符合诊断标准的胆汁反流性胃炎患者60例分为两组。一组口服胃动方，每日1剂；另一组口服莫沙必利5mg，3次/d；两组均同时服用铝碳酸镁1g，3次／d，疗程为4周。于治疗前后进行临床症状、胃镜下胆汁反流程度分级和胃黏膜病理积分评价。结果胃动方组显效率为43．3％，总有效率为86．7％；莫沙必利组显效率为33．3％，总有效率为83．3％。两组均可明显改善患者的胃黏膜炎症，与治疗前比较差异有统计学意义（P〈0．05或P〈0．01）。胃动方组在改善患者的上腹痛、烧心、饱胀、恶心或呕吐等临床症状及胃黏膜炎症方面的疗效与莫沙必利组的疗效相近。结论胃动方联合铝碳酸镁是治疗胆汁反流性胃炎的有效方法之一。

Objective To observe the effect of Weidongfang and hydrotalcite in treatment of bile reflux gastritis. Methods Bile reflux gastritis were randomly assigned to 2 groups. 30 cases in the Weidongfang group were treated with Weidongfang and hydrotalcite; 30 cases in the mosapride group were treated with mosapride and hydrotalcite ; and the course of treatment was 4 weeks for all. The clinical symptoms of bile reflux gastritis, the classify of extent of bile reflux and the accumulated points of pathological change of the gastric mucosa below gastroscope were evaluated before and after treatment. Results The significant and total effective rate in the Weidongfang group were 33.3% and 86. 7%, Mosapride group 43.3% and 83.3%. But the classify of extent of bile reflux and the accumula- ted points of pathological change of the gastric mucosa of Weidongfang group were Similar to Mosapride group below gastroscope. Conclusion Weidongfang and hydrotalcite were effective medicine in treatment of bile reflux gastritis.