摘要
为评价用 MDT 后 MB 麻风的远期复发率,对江苏扬州地区和东台市1983～1993年登记的711例 MB 麻风连续用 MDT 至皮肤查菌阴性,从中选择疗前 BI≥2.6和1990年12月以前停药者进行随访,共157例,其中65例(41.40%)已停药随访7年以上;达到皮肤查菌阴性者,用 MDT 时间最短者为2年,最长者为6年(平均为47.7月);治疗4年时的阴转率为75.16%,5年为97.45%,5年内 BI 年均下降0.69;共随访946人年,平均每例随访6.02年,有2例分别在停药3年和4.5年时复发(1.3%或2.1/1000人年)。本组资料表明,高菌量的 MB,用 MDT 后的复发率并不更高。应该加强监测,进一步积累复发资料来评价 MDT 的远期疗效。
In 1983 to 1993,711 cases of MB leprosy have been registered and treated with WHO—MDT until their skin smears became negative in Yangzhou and Dongtai,Jiangsu.Among them 157 cases who had BI of≥2.6 at the beginning of treatment and stopped MDT before De- cember 1990 were followd up,of which 65(41.4%) were followed up over seven years.Their skin smears became negative within two to six years,with average time of 47.7 months after starting MDT,being within four years in 75.8% and within five years in 97.5%.For five years their BI decreased by 0.69 yearly on an average.They have been followed up for 6.02 years meanly,amounting to 9,16 person—years.Two cases were found to have relapse three and 4.5 years after stop of MDT respectively,being in relapse rate of 1.3% or 2.1/1000 person— years.So,in this group of MB leprosy patients with higher bacterial load the relapse rate was no higher.
