骨髓基质干细胞治疗椎间盘退变性疾病的研究进展
被引量:1
摘要
椎间盘(intervertebral disc,IVD)退变能导致脊柱的生物力学功能紊乱,从而影响脊柱的正常功能。对于椎间盘退变机制的研究及认识是找到能有效治疗或者阻止椎间盘退变的前提,目前认为柞间盘退变是一种与椎间盘内炎症介质和金属蛋白酶的增多引起的髓核细胞、蛋白聚糖和水含量的减少有关的疾病,其最终形态表现存椎间盘形态和功能的改变。基于这些认识,能阻断椎间盘退变或者恢复椎间盘形态和功能的生物治疗,将会在椎间蕊退变性疾病的治疗中发挥重要作用。
出处
《中国脊柱脊髓杂志》
CAS
CSCD
北大核心
2009年第4期304-306,共3页
Chinese Journal of Spine and Spinal Cord
参考文献27
-
1Pittenger MF,Mackay AM,Beck SC,et al. Multilineage potential of adult human mesenchymal stem cells[J].Science,1999, 284(5411 ) : 143-147.
-
2Pountos l,Jones E,Tzioupis C,et al. Growing bone and cartilage: the role of mesenchymal stem cells[J].J Bone Joint Surg Br,2006,88 (4) :421-426.
-
3Murphy JM,Fink DJ,Hunziker EB,et al. Stem cell therapy in a caprine model of osteoarthritis [J].Arthritis Rheum,2003,48 (12) : 3464-3474.
-
4Sakai D,Mochida J,Yamamoto Y,et al.Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc:a potential therapeutie model for disc degeneration[J].Biomaterials, 2003,24 ( 20 ) : 3531-3541.
-
5Sakai D,Mochida J,Iwashina T,et al. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc [J].Biomaterials, 2006,27(3) :335-345.
-
6Richardson SM,Curran JM,Chen R,et al.The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-1-lactic acid (PLLA) scaffolds[J].Biomaterials, 2006,27 (22) : 4069-4078.
-
7Sakai D,Mochida J,Iwashina T,et al. Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model:potential and limitations for stem cell therapy in disc regeneration[J].Spine, 2005,30 (21 ) : 2379-2387.
-
8Bhardwaj R, Midha R. Synchronous lumbar disc herniation in adult twins:case report[J].Can J Neurol Sci,2004,31 (4):554- 557.
-
9Jim JJ,Noponen-Hietala N,Cheung KM,et al.The TRP2 allele of COL9A2 is an age -dependent risk factor for the development and severity of intervertebral disc degeneration[J]. Spine, 2005,30 (24) : 2735-2742.
-
10Sethe S,Scutt A,Stolzing A.Aging of mesenchymal stem cells [J].Ageing Res Rev,2006,5(1 ) :91-116.
二级参考文献23
-
1李华壮,周跃.椎间盘组织工程研究进展[J].中华骨科杂志,2005,25(5):316-318. 被引量:14
-
2李旭,侯筱魁,李惠武,汤亭亭,郭刚,裴国献.“穿刺抽取髓核”诱导腰椎间盘退变的时间相关性评估[J].中华实验外科杂志,2007,24(6):672-674. 被引量:8
-
3Sakai D,Mochida J,Yamamoto Y,et al.Transplantation of mesenchymal stem cells embedded in Atelocollagen? gel to the intervertebral disc:a potential therapeutic model for disc degeneration[J].Biomaterials,2003,24(20):3531-3541.
-
4Grande DA,Breitbart AS,Mason J,et al.Cartilage tissue engineering:current limitations and solutions[J].Clin Orthop Relate Res,1999,(367 Suppl):176-185.
-
5Seto H,Tanaka S,Seto H,et al.Relationship between gene transfer and cartilage tissue engineering[J].Clin Calcium,2004,14(7):72-75.
-
6Gruber HE,Hanley EN Jr.Biologic strategies for the therapy of intervertebral disc degeneration[J].Expert Opin Biol Ther,2003,3(8):1209-1214.
-
7Guiot BH,Fessler RG.Molecular biology of degenerative disc disease[J].Neurosurgery,2000,47(5):1034-1040.
-
8Pittenger MF,Mackay AM,Beck SC,et al.Multilineage potential of adult human mesenchymal stem cells[J].Science,1999,284(5411):143-147.
-
9Bai X,Xiao Z,Pan Y,et al.Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes[J].Biochem Biophys Res Commun,2004,325 (2):453-460.
-
10Thompson JP,Oegema TR Jr,Bradford DS. Stimulation of mature canine intervertebral disc by growth factors [J].Spine, 1991,16(3) :253-260.
共引文献6
-
1方忠,李锋,游洪波,李光辉,熊伟.共同培养骨髓基质干细胞对髓核细胞增殖分化的影响[J].中国组织工程研究与临床康复,2007,11(28):5548-5552. 被引量:3
-
2刘航涛,王万明,林智军.间充质干细胞诱导分化椎间盘细胞的研究进展[J].中国修复重建外科杂志,2007,21(11):1247-1249.
-
3许建文,熊昌源.转化生长因子β1与椎间盘退变的相关研究[J].中国组织工程研究与临床康复,2008,12(20):3935-3938. 被引量:3
-
4许建文,谢伟星,钟远鸣,陈晶,黄小琪,尹利军.广西壮族人群转化生长因子β1基因多态性与腰椎间盘突出症血瘀证的关联性[J].中国组织工程研究与临床康复,2009,13(33):6577-6580. 被引量:6
-
5陈文坚,李锋,杨晶,周松,方忠.三维共培养兔髓核细胞诱导骨髓间充质干细胞分化(英文)[J].中国组织工程研究与临床康复,2009,13(49):9783-9786. 被引量:3
-
6张涛,姬振伟,钱济先.细胞支架研究进展[J].现代生物医学进展,2011,11(1):165-168. 被引量:3
同被引文献17
-
1龙启才,邱建波.威灵仙、秦艽、桑寄生醇提物体外对淋巴细胞和环氧酶的影响[J].中药药理与临床,2004,20(4):26-27. 被引量:61
-
2陈德胜,金群华,李燕,朱凯.一种大鼠腰椎间盘退变模型的建立[J].中华实验外科杂志,2006,23(4):625-626. 被引量:17
-
3Hoogendoom WE, van Poppel MN, Bongers PM, et al. Systemat- ic review of psychosocial factors at work and private life as risk factors for back pain[J].Spine (Phila Pa 1976),2000,25(16): 2114-2125.
-
4Razaq S, Wilkins R J, Urban JP. The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus[J]. Eur Spine J,2003,12(4):341-349.
-
5Cinotti G, Della RC, Romeo S, et al. Degenerative changes of por- cine intervertebral disc induced by vertebral endplate injuries[J]. Spine (Phila Pa 1976),2005,30(2): 174-180.
-
6Goupille P, Jayson MI, Valat JP, et al. Matrix metalloproteinases: the clue to intervertebral disc degeneration?[J]. Spine (Phila Pa 1976),1998,23(14):1612-1626.
-
7Seguin CA, Bojarski M, PiUiar RM, et al. Differential regulation of matrix degrading enzymes in a TNFalpha-induc.ed model of nu- cleus pulposus tissue degeneration[J].Matrix Biol,2006,25(7): 409-418.
-
8Kanemoto M, Hukuda S, Komiya Y, et al study of matrix metalloproteinase-3 and tissue inhibitor of metal- loproteinase-1 human intervertebral discs[J]. Spine (Phila Pa1976),1996,21(1):1-8.
-
9Vo NV, Hartman RA, Yurube T, at al. Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration[J].Spine J,2013,13(3):331-341.
-
10Canbay S, Turhan N, Bozkurt M, et al. Correlation of matrix me- talloproteinase-3 expression with patient age, magnetic resonance imaging and histopathological grade in lumbar disc degeneration [J]. Turk Neurosurg,2013,23(4):427-433.
-
1肖运祥,陈海丹,刘杨.胸腰椎压缩性骨折椎间盘形态学观察及临床意义[J].中国医师进修杂志,2017,40(1):53-55. 被引量:7
-
2姚啸生,李洪久,刘歆,王靖,唐天驷.短节段椎弓根内固定治疗胸腰椎爆裂性骨折远期疗效分析[J].中国中医骨伤科杂志,2009,17(8):27-29. 被引量:5
-
3崔全起,姜宏,施杞.国外椎间盘研究新进展[J].中国中医骨伤科,1998,6(6):52-55. 被引量:20
-
4于跃.磨人的疾病更需要耐心地面对[J].健康管理,2016,0(12):40-42.
-
5邓莉,梅志强,严冬梅,李明.经静脉移植骨髓基质干细胞治疗脊髓损伤后碱性成纤维生长因子表达变化[J].泸州医学院学报,2012,35(3):251-253.
-
6刘彬彬,张柳,田发明,王文雅.椎间盘退变动物模型及降钙素治疗的研究进展[J].中国修复重建外科杂志,2014,28(8):1051-1054. 被引量:6
-
7朱洪勋,韩成龙.椎间盘退变机制及动物模型建立的研究进展[J].中国矫形外科杂志,2011,19(5):389-391. 被引量:5
-
8顾军,谢林,康然,王庚启.椎间盘退变机制研究概况[J].世界中医药,2013,8(6):700-702. 被引量:5
-
9杨敦欣.腰椎间盘病变X线、CT诊断100例临床分析[J].基层医学论坛,2004,8(9):839-839.
-
10陈国仙,叶道明,王万明.椎间盘退变机制研究进展[J].脊柱外科杂志,2006,4(3):174-178. 被引量:7