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骨髓基质干细胞治疗椎间盘退变性疾病的研究进展 被引量：1

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摘要 椎间盘（intervertebral disc，IVD）退变能导致脊柱的生物力学功能紊乱，从而影响脊柱的正常功能。对于椎间盘退变机制的研究及认识是找到能有效治疗或者阻止椎间盘退变的前提，目前认为柞间盘退变是一种与椎间盘内炎症介质和金属蛋白酶的增多引起的髓核细胞、蛋白聚糖和水含量的减少有关的疾病，其最终形态表现存椎间盘形态和功能的改变。基于这些认识，能阻断椎间盘退变或者恢复椎间盘形态和功能的生物治疗，将会在椎间蕊退变性疾病的治疗中发挥重要作用。
作者 王超锋 阮狄克
机构地区 海军总医院
出处 《中国脊柱脊髓杂志》 CAS CSCD 北大核心 2009年第4期304-306,共3页 Chinese Journal of Spine and Spinal Cord
关键词 椎间盘退变性疾病 干细胞治疗 骨髓基质 椎间盘退变机制 椎间盘形态 金属蛋白酶 DISC 功能紊乱
分类号 R681.53 [医药卫生—骨科学] R318.04 [医药卫生—生物医学工程]
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参考文献27

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二级参考文献23

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共引文献6

同被引文献17

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中国脊柱脊髓杂志
2009年 第4期

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