芳香化酶P450在肥大乳房乳腺组织中的表达

The expression of aromatase P450 in the mammary gland of hypertrophic breast

目的探讨芳香化酶P450在肥大乳房乳腺组织中的表达情况。方法采用免疫组织化学SP法，检测28例肥大乳房和12例正常体积乳房乳腺组织中芳香化酶P450的表达情况。并应用SPSS13．0统计软件进行统计分析，组间比较采用Fisher精确概率检验。结果在肥大乳房组28例患者中有11例呈芳香化酶阳性表达，阳性表达率39．29％；在正常体积乳房组12例患者中无芳香化酶阳性表达，组问比较差异有统计学意义（P〈0．05）。腺性肥大组与脂性肥大组的芳香化酶阳性表达率比较差异无统计学意义（P〉0．05）。在分别按哺乳史和乳房肥大及下垂的程度的分组中，芳香化酶阳性表达率比较差异均无统计学意义（P〉0．05）。结论芳香化酶P450在肥大乳房乳腺组织中存在过表达，可能参与肥大乳房的形成。

Objective To investigate the expression of aromatase P450 in the mammary gland of hypertrophic breast. Methods The expression of aromatase P450 in the mammary gland was detected by SP immunohistochemistry in 28 eases of hypertrophic breasts and 12 cases of normal volume breasts. The results were analysed by SPSS 13.0, and comparison among groups was performed by Fisher＇ s exact test, Results The positive expression rate of aromatase P450 in hypertrophic group was 39.29%, while there was no positive expression in normal group, showing a significant defferenee between the two groups （ P 〈 0.05） . There was no signifieant difference between the gland hyperplasia group and adipose hyperplasia group （ P 〉 0.05 ） . There were also no significant differenee between the groups with different laetation history or different extent of hypertrophy and mastoptosis （ P 〉 0.05）. Conclusions Overexpression of aromatase P450 in mammary gland may be related to the development of hypertrophic breast.