奈达铂治疗晚期食管癌临床观察

Clinical Study of Nedaplatin in the Treatment of Advanced Esophageal Carcinoma

目的观察奈达铂联用5-氟尿嘧啶、亚叶酸钙治疗晚期食管癌的临床疗效和不良反应。方法28例食管癌患者随机分为治疗组和对照组,治疗组应用奈达铂80mg/m2,d1,5-氟尿嘧啶500mg/m2d1～d5,亚叶酸钙200mg/m2,d1～d5。对照组应用顺铂20mg/m2,d1～d3,5-氟尿嘧啶500mg/m2d1～d5,亚叶酸钙200mg/m2,d1～d5;两组均为21d一个周期,两个周期后评价疗效。结果治疗组总有效率53.3%,对照组总有效率46.2%。两组比较差异有显著性(P<0.05)。治疗组不良反应主要为白细胞和血小板减少发生率44.6%,对照组不良反应主要为恶心、呕吐,发生率48.6%,两组比较差异有显著性(P<0.05)。结论奈达铂治疗晚期食管癌疗效确切,不良反应可以耐受。

Objective To evaluate the response rate and the side effect of nedaplatin in the treatment of patients with advanced esophageal carcinoma. Methods 26 patients with advanced esophageal carcinoma were divided randomly into NDP group and control group. The therapeutic regimen for NDP group was NDP 80mg/m^2,ivgtt,on dayl and 5-Fu 500mg/m2 ivgtt on day1 - 5 calcium folinate（CF）200mg/m62 d1-5. The therapeutic regimen for control group was DDP 20mg/m^2,ivgtt,On days1-5 and 5-Fu 500mg/m^2 ivgtt,On days1-5,calcium folinate （CF） 200mg/m^2 d1-5, Twenty one day was a cycle for two regiments. The efficacy was evaluated after two cycles of treatment. Results The effective rates in NDP group and control group were 50% and 43.48% respectively. And there was no statistical difference between them（P〈 0.05 ）. The main side effect of NDP group was thrombocytopenia, and the incidence were 42.86%; while the side effects of control group were nausea and vomiting,and the incidence were 47.87%. There was statistical difference between the two groups（P〈 0.05）. Conclusion The combination of NDP and 5-Fu show sure efficacy and slight side effects in the treatment of advanced esophageal carcinoma. It can be used widely in clinic.